Watch Carefully (one)mitotane decreases amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is a robust inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for possible dosage changes.diazepam decreases amounts of acetaminophen rectal by escalating metabolis